mr eric ndombi

Title/Qualifications: Ph.D
Department/Unit/Section: Pathology
Contact Address: P.O. Box 43844 Nairobi, Kenya
Position: Chairperson & Lecturer
Area of Specialization: Immunology 

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Research Interests

My research focuses on the dynamics and interplay of the human immune system and infectious diseases.  My previous work was on the effect of mass praziquantel treatment on anti-schistosome immune responses in school children and the impact of infection with schistosomiasis mansoni on vaccine responses. I am now part of an ongoing collaborative study with Prof. Timothy Anderson, Dr. Frederick Chevalier, and Dr. Winka LeClech of Texas Biomedical Research Institute in San Antonio, Texas, USA and Professor Phillip LoVerde of the University of Texas Health Science Center, San Antonio, Texas, USA. My collaborative research work in schistosomiasis control is based at the Kenya Medical Research Institute’s Centre for Global Health Research (KEMRI-CGHR) campus where I run a well-established snail and hamster rearing facility with all requisite infrastructure for supporting field activities in a schistosomiasis endemic area near Lake Victoria.  My plan is to build a strong research team in the field of infectious diseases while augmenting my knowledge and skills in research ethics, population genetics, genomics and computational biology. I am especially committed to research that will continue to advance the work of schistosomiasis control, with the focus now being to investigate praziquantel resistance in schistosomes, identifying mutations underlying resistance in schistosome parasites from the field in western Kenya. I am also currently involved in collaborative research work on Covid-19 epidemiology and persistence and immunity, together with colleagues at Kenyatta University, KEMRI and Kenyatta National Hospital.

Collaborations: Kenya Medical Research Institute’s Center for Global Health Research (KEMRI-CGHR) in Kisumu, University of Georgia’s Center for Tropical and Emerging Global Diseases (UGA-CTEGD), Centers for Disease Control and Prevention (CDC)

Publications

  1. Schlosser-Brandenburg J, Midha A, Mugo RM, Ndombi EM, Gachara G, Njomo D, Rausch S and Hartmann S (2023) Infection with soil-transmitted helminths and their impact on coinfections.  Parasitol.2:1197956. doi: 10.3389/fpara.2023.1197956
  2. Mulakoli, F., Gachara, G., Ndombi, E., & Khamadi, S. (2023). Dengue Virus Surveillance and Blood Safety: A One Health Perspective. IntechOpen. doi: 10.5772/intechopen.109413
  3.  Abudho BO, Guyah B, Ondigo BN, Ndombi EM, Ireri E, Carter JM, Riner DK, Kittur N, Karanja DMS, Colley DG. Evaluation of morbidity in Schistosoma mansoni-positive primary and secondary school children after four years of mass drug administration of praziquantel in western Kenya. Infect Dis Poverty. 2020 Jun 15;9(1):67. doi: 10.1186/s40249-020-00690-7. PubMed PMID: 32539826

  4. Harrison K. Korir, Diana K. Riner, Emmy Kavere, Amos Omondi, Jasmine Landry, Nupur Kittur, Eric M. Ndombi, Bartholomew N. Ondigo, W. Evan Secor, Diana M. S. Karanja and Daniel G. Colley. Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination. Trop. Med. Infect. Dis. 2018, 3, 100; doi:10.3390/tropicalmed3030100
  5. Bartholomew N. Ondigo, Erick M. O. Muok1, John K. Oguso, Sammy M. Njenga, Henry M. Kanyi, Eric M. Ndombi, Jeffrey W. Priest, Nupur Kittur, William Evan Secor, Diana M. S. Karanja and Daniel G. Colley. Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya. Front. Immunol., 18 June 2018 https://doi.org/10.3389/fimmu.2018.01402
  6. Bernard O. Abudho, Eric M. Ndombi, Bernard Guya, Jennifer M. Carter, Diana K. Riner, Nupur Kittur, Diana M. S.Karanja, W. Evan Secor and Daniel G.Colley. Impact of Four Years of Annual Mass Drug Administration on Prevalence and Intensity of Schistosomiasis among Primary and High School Children in Western Kenya: A Repeated Cross-sectional Study. Am J Trop Med Hyg. 2018.17-0908. Doi:10.4269/ajtmh
  7. Eric M. Ndombi, Bernard Abudho, Nupur Kittur, Harrison Korir, Diana K. Riner, W. Evan Secor, Diana Karanja and Daniel G. Colley; Effect of Rour Rounds of Annual School-Wide Mass Praziquantel Treatment for Schistosoma Mansoni Control on Schistosome-Specific Immune Responses. Parasite Immunol. 31 March 2018. https://doi.org/10.1111/pim.12530
  8. Bartholomew N. Ondigo, Eric M. Ndombi, Sarah C. Nicholson, John K. Oguso, Jennifer M. Carter, Nupur Kittur, W. Evan Secor, Diana M.S. Karanja and Daniel G. Colley. Functional studies of T regulatory lymphocytes in human schistosomiasis in western Kenya. Am J Trop Med Hyg. 98:6, Jun 2018, 1770 – 1781. DOI: https://doi.org/10.4269/ajtmh.17-0966
  9. Diana K. Riner, Eric M. Ndombi, Jennifer M. Carter, Amos Omondi, Nupur Kittur, Emmy Kavere, Harrison K. Korir, Briana Flaherty, Diana Karanja, Daniel G. Colley; Schistosoma mansoni infection can jeopardize the duration of protective levels of antibody responses to immunizations against hepatitis B and tetanus toxoid. PLOS NTDs 2016. https://doi.org/10.1371/journal.pntd.0005180
  10. Eric M. Ndombi, Budambula Valentine, Mark W. Kilongosi, Francis O. Musumba, Joseph Karanja, Jesca O. Wesongah, Samwel A. Bonuke, Aabid A Ahmed, Raphael Lihana, and Tom Were; Plasma Adiponectin Levels in Hepatitis C and HIV-1 Mono- and Co-Infected Antiretroviral Treatment Naive and Exposed Injection Drug Users from Coastal Kenya. Endocrine connections journal 2015. doi: 10.1530/EC-15-0071

GRANTS
2021-2022: MERCK Schistosomiasis Research Grant Initiative

Project Title: Molecular Surveillance of Praziquantel Resistance
Role: Principal Investigator (PI)
Collaborations: Kenya Medical Research Institute, Texas Biomedical Research Institute
Overall Goal: The objectives of this study will be to (i) screen for TRPM-PZQ sequence variation in field collected schistosome populations in Western Kenya, and (ii) identify potential key mutation(s) in TRPM-PZQ gene which might play a role in PZQ treatment failure in ‘persistent hotspots’, Kenyan high schistosome transmission area.
Grant Value: EURO 30,000

 

Conferences

  • Oct-Dec 2021 Southern African Research and Innovation Management Association (SARIMA)-University of Witwatersrand, South Africa, Digital Campus SARIMA Programme Evaluation Course
  • Aug-Oct 2021 Southern African Research and Innovation Management Association (SARIMA)-University of Witwatersrand, South Africa, Digital Campus SARIMA Intellectual Property, Technology Transfer & Commercialisation course
  • June-August 2021 Southern African Research and Innovation Management Association (SARIMA)-University of Witwatersrand, South Africa, Digital Campus Research Grants and Contracts Management online course
  • 8-9 June 2021 Global Schistosomiasis Alliance: Schistosomiasis Research 2021 Virtual Meeting
  • 21-24 May 2021 International Network Of Research Management Societies (INORMS) Conference, South Korea 2021. Virtual Attendee
  • April 2021 International Day of Immunology Webinar: Immunology in the time of Covid-19: Achievements, Challenges and Opportunities
  • April-May 2021 Southern African Research and Innovation Management Association (SARIMA)-University of Witwatersrand, South Africa, Digital Campus. Fundamentals of Research Management online course
  • July/October 2020 Southern African Research and Innovation Management Association (SARIMA)-University of Witwatersrand, South Africa, Digital Campus Research Ethics online course
  • June/July 2020 SARIMA Virtual Grants Management course; Southern African Research Innovation Management Association.
    Gender in Science, Technology and Innovation Course
  • Feb/March 2019 Texas Biomedical Research Institute, Training in laboratory methods on hamster handling, euthanasia, infection with schistosomes, and perfusion and lactate assay, San Antonio, Texas, USA
  • March 2018 14th Spring School on Immunology in Ettal, Bavaria, Germany (Travel award)
  • January 2018 10th Center For AIDS Research (CFAR) East Africa Collaborative Scientific Symposium, Infectious Diseases Institute, Makerere University, Kampala.
  • Oral Presentation titled: Effect of four rounds of annual praziquantel mass drug administration on anti-schistosome immune responses in school children in Western Kenya
  • October 2015 American Society of Tropical Medicine and Hygiene (ASTMH) annual meeting 2015, The Marriott Philadelphia downtown, Philadelphia, Pennsylvania, USA. Oral Presentation titled: Effect of Mass Drug Administration with Praziquantel on Anti-Schistosome Immune Responses in School Children from Western Kenya.
  • June 2015 Federation of Clinical Immunological Societies (FOCIS) Annual Meeting, San Diego, California, USA.
    Oral Presentation titled: Effect of one round of mass drug administration on immune correlates of protection against schistosomiasis in school children from western Kenya.
  • June 2015 Basics of Clinical Immunology Course, Federation of Clinical Immunological Societies (FOCIS), Hilton Bayfront, San Diego, California, USA. (Travel award)
  • June 2015 Federation of Clinical Immunological Societies Annual meeting (FOCIS 2015) Oral presentation:
  • Dec 2014 Ruggero Ceppellini Advanced School of Immunology; Maternal immune system in pregnancy course; Castellammare di Stabia (Naples), Italy. (Travel award).