Title/Qualifications: Dr.

Designation/Position: Senior Lecturer
Department/Unit/Section: Biochemistry, Microbiology and Biotechnology
Contact address: P.O. Box 1 Uthiru 00605
Area of Specialization: Molecular Genetics

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ORCID ID: 0000-0002-0102-6291

Google Scholar: https://scholar.google.com/citations?user=P6wgtVoAAAAJ&hl=en

Research interests: Molecular Genetics/Toxicology

Publications

  • Kibugu J., Mburu D., Munga L., Lusweti F., Grace D and Lindahl J. (2022). Mycotoxin hazards in the Kenyan food and feed market – A retrospective study. African Journal of Food, Agriculture, Nutrition and Development, 22, 19306 – 19325.
  • Gichuru M.J., Mwonjoria J.K. M., Mburu N.D., Menza C.N. (2022). Toxicity of Toddalia asiatica is associated with microcephaly and hypochondroplasia in mice. The Journal of Phytopharmacology 2022; 11(6):386-390.
  • Kibugu J., Mdachi R., Munga L., Mburu D., Whitaker T., Huynh T.P., Grace D., Lindahl J.F. (2021). Improved sample selection and preparation methods for sampling plans used to facilitate rapid and reliable estimation of aflatoxin in chicken feed. Toxins 13, 216.
  • Kibugu, J., Munga, L., Mburu, D., Grace, D., Lindahl, J.F. (2021). Exposure to chronic dietary aflatoxin poisoning is potentially a compromising condition in COVID-19 patients in Africa. African Journal of Food, Agriculture, Nutrition and Development 21 (6).
  • Chieng B., Okoyo C., Simiyu E., Gichuki P., Mwatele C., Kepha S., Njenga S., Mburu D. (2021). Comparison of quantitative polymerase chain reaction, Kato-Katz and circulating cathodic antigen rapid test for the diagnosis of Schistosoma mansoni infection: A cross-sectional study in Kirinyaga County, Kenya. Current Research in Parasitology & Vector-Borne Diseases. https://doi.org/10.1016/j.crpvbd.2021.100029
  • Gitahi S.M. , Ngugi M.P. , Mburu D.N. , Machocho A.K. (2021). Contact Toxicity Effects of Selected Organic Leaf Extracts of Tithonia diversifolia (Hemsl.) A. Gray and Vernonia lasiopus (O. Hoffman) against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae). International Journal of Zoology. https://doi.org/10.1155/2021/881 4504
  • Gitahi S.M., Ngugi M.P., Mburu D.N. and Machocho A.K. (2021). Repellent Effects of Selected Organic Leaf Extracts of Tithonia diversifolia (Hemsl.) A. Gray and Vernonia lasiopus (O. Hoffman) against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae). The Scientic World Journal.  https://doi.org/10.1155/2021/2718629
  • Masibo K.M, Mwonjoria J.M., Mburu D.N. (2020). Efficacy and safety of prednisolone in the management of alcohol-Induced adverse effects in a Rat Model. Journal of Alcoholism and Drug Dependence 8, 1-7.
  • Mrama J.I., Ngeranwa J.N., Mburu D.N., Jaoko W. and Sekadde-Kigondu C.B. (2018). A prospective study on the changes of clinical values in HIV-infected patients attending Kenyatta National Hospital Comprehensive Care Center. Journal of AIDS and HIV Research. Journal of AIDS and HIV Research 10, 56-63.
  • Mrama J.I., Ngeranwa J.N., Mburu D.N., Jaoko W., Sekadde-Kigondu C.B. and Wanzala P. (2018). Prospective changes in serum levels of some proinflammatory cytokines and erythropoietin among anaemic HIV-infected patients attending Kenyatta National Hospital Comprehensive Care Centre. International Journal of Sciences: Basic and Applied Research 36, 90- 107.
  • Muia P.K., Ngugi M.P., Mburu D.N. (2017). Performance of GeneXpert® assay in detecting pulmonary tuberculosis and rifampicin resistance in patients attending Kitui county hospital, Kenya. Journal of Tropical Diseases and Public Health 5: 246. doi:10.4172/2329-891X.1000246.
  • Mungiria J., Gicheru M., KaviliD., Mburu D. (2017). Association between malnutrition and immunoglobulin G Responses to crude asexual falciparum schizont lysates in children attending Ishiara hospital, Embu County, Kenya. Journal of Applied Life Sciences International 11, 1-14.
  • Ireri J., Ngeranwa J., Mburu D., Jaoko W., Sekadde-Kigondu C. and Wanzala P. (2017). Prospective changes in serum levels of some proinflammatory ctokines and erythropoietin among anaemic HIV – infected Patients attending Kenyatta National Hospital Comprehensive Care Centre. International Journal of Sciences: Basic and Applied Research 36, 90 – 107.
  • Onyango T.O., Mburu D.N., Ngugi M.P., Kamau J.K., Juma K.K. (2017). Effects of maalox plus® antacid and pureCal® calcium supplements on physical characteristics, body weight, tissue minerals and histopathology of Rats Subjected to Alcohol Intoxication. Journal of Clinical and Experimental Pharmacology 7, doi:10.4172/2161-1459.1000237.
  • Onyango T.O., Mburu D.N., Ngugi M.P., Kamau J.K., Juma K.K. (2017). Effects of maalox Plus® antacid and pureCal® calcium supplements on haematological and biochemical parameters of rats subjected to alcohol intoxication. Journal of Alcoholism and Drug Dependence 5, doi: 10.4172/2329-6488.1000265.
  • Kariuki D.M., Gaichu D.M., Mburu D.N., Ngugi M.P. (2017). In vivo safety of dichloromethane-methanolic extract of Allium sativum in normal mice. Journal of Drug Metabolism and Toxicology 8, doi:10.4172/2157-7609.1000223.
  • Gaichu D.M., Mawia A.M., Gitonga G.M., Ngugi M.P, Mburu D.N. (2017). Phytochemical screening and antipyretic activities of dichloromethane-methanolic leaf and stem bark extracts of Ximenia americana in rat models. Journal of Herbmed Pharmacology 6, 107-113.
  • Gaichu D.M., Nthiga P.M., Kariuki D.M., Ngugi M.P., Mburu D.N. (2017). Anti-inflammatory activities of dichloromethane-methanolic leaf and stem bark extracts of Ximenia americana in mice models. J Herbmed Pharmacology 6, 55-61.
  • Ouma S.O., Ngeranwa J.N., Juma K.K. & Mburu D.N. Seasonal variation of the physicochemical and bacteriological quality of water from five rural catchment areas of Lake Victoria basin in Kenya (2016). Journal of Environmental Analytical Chemistry 4, doi:10.4172jreac.1000170.
  • Osano K.O., Nyamai D.W., Ogola P.E., Ouko R.O., Arika W.M., Bina M.W., Mburu D.N. and Ngugi M.P. (2016). Evaluation of in vivo toxicity of dichloromethane: methanolic Leaf extracts of Prosopis juliflora in female wistar albino rats. Journal of Drug Metabolism and Toxicology 7, doi:10.4172/2157-7609.1000200.
  • Mwonjoria J., Umar A., Juma K., Kahiga T., Ngugi P., Mburu D., Wanyonyi A., Githinji C., Ngeranwa J. (2016). Anti-inflammatory activity of Craterostigma pumilum (hochst) is associated with hyperalgesia. International Journal of Pharmacology and Toxicology 4, 169-173.
  • Wanyama F.M., Kigondu C.S., Mburu D.N., Ngugi N.N., Kiboi N. (2016). Evaluation of high density lipoprotein cholesterol as a predictor of diabetic nephropathy in type 1 diabetic patients. Clinical and Medical Biochemistry Open Access 2, doi:10.4172/2471-2663.1000117
  • Abuto J. O., Muchugi A., Mburu D., Machocho A. K., Karau G. M. (2016). Variation in antimicrobial activity of Warburgia ugandensis extracts from different populations across the Kenyan Rift Valley. Journal of Microbiology Research 6, 55-64. DOI: 10.5923/j.microbiology.20160603.02
  • Nthiga PM, Kamau JK, Safari VZ, Mwonjoria JK, Mburu DN, and Ngugi MP (2016) Antipyretic potential of methanolic stem bark extracts of Harrisonia abyssinica Oliv and Landolphia buchananii (Hallier )  Stapf in wistar rats.  Journal of Applied Pharmacy 8, 227. doi: 10.4172/1920-4159.1000227.
  • Nthiga PM, Kamau JK, Safari VZ, Ngugi MP, Mburu DN (2016). Antinociceptive activity of methanolic stem bark extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in mice model. Journal of Pain and Relief 5,doi:10.4172/2167-0846.1000253.
  • Juma K.K., Maina S.G., Muriithi J.N., Mwangi B.M., Mworia K.J., Mwonjoria M.J., Ngeranwa J.N. & Mburu N.D. (2015). Protective effects of Urtica dioica and cimetidine® on liver function following acetaminophen induced hepatotoxicity in mice. Journal of Developing Drugs, 4, doi:10.4172/2329-6631.1000130.
  • Gitahi S.M., Mwangi B.M., Njagi J.M., Mworia J.K., Juma K.K., Aliyu U.,  Mwonjoria K.J., Njoroge W.A., Ngugi M.P., & Mburu N.D. (2015). Antipyretic properties of dichloromethane: methanolic leaf and root bark extracts of Carissa edulis in rats. Asian Journal of Biomedical and Pharmaceutical Sciences. 5, 12-20.
  • Munyasya J.N., Juma K.K., Burugu M.W., Mburu D.N. & Okuku E.O. (2015). Biochemical effects of sewage pollution on the benthic organism Nerita polita. Environmental and Analytical Toxicology. S7:004 doi:10.4172/2161-0525.S7-006.
  • Gitahi S.M., Juma K.K., Mwangi B.M., Njagi J.M., Mworia J.K., Aliyu U., Mwonjoria K.J., Njoroge W.A., Mburu N.D., Ngugi M.P. (2015). Antinociceptive properties of dichloromethane: methanolic leaf and root bark extracts of Carissa edulis in rats. Journal of Phytopharmacology, 4, 106-112.
  • Mwangi B.M., Gitahi S.M., Njagi J.M., Mworia J.K., Aliyu U., Njoroge W.A.,  Mwonjoria K.J., Ngugi M.P., Mburu N.D. (2015). Antiinlammatory properties of dichloromethane:methanolic leaf extracts of Caesalpinia Volkensii and Maytenus Obscura in animal models. International Journal of Current Pharmaceutical Research, 7, 83-87.
  • Juma K.K., Ngeranwa J.N. & Mburu N.D. (2015). A Review of the biochemical, hematological and histological modulations in acetaminophen induced hepatoxicity and the potential of Urtica dioica in the regeneration of the Liver. Drug Metabolism and Toxicology, 6,   doi: 10.4172/2157-7609.1000182.
  • Juma K.K. Fulakeza R.M.J., Ngeranwa J.N., Ngugi M.P. & Mburu N.D. (2015). Evidence based phytopharmacological potential of herbal extracts in post-ingestion management of mycotoxins in animal models. Journal of Clinical Toxicology, 5, doi:10.4172/2161-0495.1000254.
  • Lelo A.E., Mburu D.N.,Magoma G.N., Mungai B.N., Kihara J.H., Mwangi I.N., Maina G.M., Kinuthia J.M., Mutuku M.W., Loker E.S., Mkoji G.M., Steinauer M.L. (2014). No apparent reduction in schistosome burden or genetic diversity following four years of school-based mass drug administration in Mwea, Central Kenya, a heavy transmission area. PLOS Neglected Tropical Diseases, 8, doi:10.1371/journal.pntd. 0003221.
  • Misigo D., Mwaengo D. & Mburu D. (2014). Molecular detection and phylogenetic analysis of Kenyan human bocavirus isolates. Journal of infection in Developing Countries, 8, 221-227.
  • Gitahi S.M., Ngugi M.P., Mburu D.N. and Machocho A.K. (2021). Repellent Effects of Selected Organic Leaf Extracts of Tithonia diversifolia (Hemsl.) A. Gray and Vernonia lasiopus (O. Hoffman) against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae). The Scientic World Journal.  https://doi.org/10.1155/2021/2718629
  • Masibo K.M, Mwonjoria J.M., Mburu D.N. (2020). Efficacy and safety of prednisolone in the management of alcohol-Induced adverse effects in a Rat
  • Mburu D.N. (2013). Differential Utilization of CCR5 Molecules from Three East African Primate Species by the HIV-1 Envelope Glycoprotein. International Journal of Biotechnology and Biochemistry, 9, 197-209
  • Agola L.E., Steinauer L., Mburu D.N., Mungai B.N., Mwangi N., Magoma G.M., Loker E.S. & Mkoji G.M. (2009). Genetic diversity and population structure of Schistosoma mansoni within human infra-populations in Mwea, central Kenya assessed by microsatellites markers. Acta Tropica, 111, 219-225.
  • Muigai A.W.T., Okeyo A.M., Kwallah A.K., Mburu, D. & Hanotte O. (2009). Characterization of sheep populations in Kenya using microsatellite markers: Implications for conservation and management of indigenous sheep populations. South African Journal of Animal Science, 39 (Supp1), 93-96.
  • Fan B., Jianlin H., Chen S-L., Mburu D.N., Hanotte O., Chen Qi-K., Zhao Shu-K. & Li K. (2008) Individual-breed assignments in caprine populations using microsatellite DNA analysis.  Small Ruminant Research 75, 154-161.
  • Agola L.E., Mburu D.N., Dejong R.J., Mungai B.N., Muluvi G.M., Njagi E.N.M., Loker E.S. & Mkoji G.M. (2006). Microsatellite typing reveals strong genetic structure of Schistosoma mansoni from localities in Kenya. Infection, Genetics and Evolution, 6, 484-490.
  • Odongo D., Oura C.A.L., Spooner P., Kiara H., Mburu D., Hanotte O.  & Bishop R.P. (2006). Genetic diversity at mini- and micro-satellite loci of Theileria parva isolated from cattle in a spectrum of geographically separated regions of Kenya. International Journal of Parasitology, 36, 937-946.
  • Mburu D.N., Ochieng J.W., Kuria S.G., Jianlin H., Kaufmann B., Rege J.E. & Hanotte O. (2003). Genetic diversity and relationships of indigenous Kenyan camel (Camelus dromedarius) populations: implications for their classification. Animal Genetics 34, 26-32.
  • Hanotte O. & Mburu D.  (2002). Genetic diversity and relationship of indigenous Kenyan camel breeds. In: Camel Breeds and Breeding in Northern Kenya-An Account of Local Breeds of Northern Kenya and Camel Breed Management of Turkana, Rendille, Gabbra and Somali Pastoralists.(Eds C.G. Hulsebusch  &  Kaufmann B.A.), pp 109-120.
  • Jianlin H., Mburu D., Ochieng J., Kaufmann B., Rege J.E. & Hanotte O. (2000). Application of New World Camelidae microsatellite primers for amplification of polymorphic loci in Old World camelids. Animal Genetics 31, 404-406.
  • Mburu D.N., Roberts T.K. & Boettcher B. (1999). Over expression of human testis antigens in Escherichia coli host cells is influenced by site of expression and the induction temperature. Biochemistry and Molecular Biology International 47, 1009-1018.
  • Mburu D.N. (1999). Maturation-related changes in distribution of lectin receptors in baboon (Papio anubis) spermatozoa during epididymal maturation. Archives of Andrology 42, 199-203.

Conferences/Workshops/Seminars              

  • Mburu D.N. (2015). Biosafety containment facilities. Preconference workshop. 4th National Biosafety Conference: Enhancing Coordination, Collaboration and Partnerships for Effective Implementation of Biosafety Framework in Kenya, Kenya School of Monetary Studies, August 11-14, Nairobi, Kenya
  • Kiboi N., Budambula,  Mburu D.N., Juma G., Nebere S.N., Ahmed A.A. & Were T. (2015). Plasma adiponectin levels in HIV-1 and tuberculosis mono and co-infected injection drug users from Mombasa, Kenya. UoN/KNH 3rd International Scientific College of Health Sciences, University of Nairobi, June 10-12, Nairobi, Kenya.
  • Kiboi N., Budambula ,  Mburu D.N., Karanja J.K.,  Nebere S.N., Juma G., Ahmed A.A., Kilongosi M.,   Musumba F.O., Choge J.K., & Were T. (2015). Plasma interferon-gamma and interleukin-10 Levels in Hiv-1 and Tuberculosis Mono- and Co-Infected Injection Drug Users from Mombasa, Kenya. The 5th Annual East African Health and Scientific Conference, Kampala Serena Hotel, March 25th-27th, Kampala, Uganda.
  • Mburu D.N. (2013). Challenges encountered in setting up a biosafety level 3 laboratory in emerging economies: The Kenyan perspective. 2nd Annual Biosafety Convention: Biosafety Advocacy for Realization of Vision 2030, Kenyatta International Conference Centre, August 7-9, Nairobi, Kenya.
  • Mburu D.N. (2013). Design, construction and maintenance of high bio-containment facilities. Preconference workshop. 2nd Annual Biosafety Conference: Biosafety Advocacy for Realization of Vision 2030, Kenyatta International Convention Centre, August 5-6, Nairobi, Kenya.
  • Mwala D.M., Mwaengo D.M. and Mburu D.N. (2011). A new parvoviridae family virus associated with respiratory infections (Kenya). 1st International Scientific Congress: Towards Optimum Health Care, College of Health Sciences, University of Nairobi, June 15-17, Nairobi, Kenya.
  • Kwallah A.B., Okeyo A.M., Mburu D., Hanotte O. and A.W.T. Muigai (2010). Genetic diversity and relationships of sheep breeds of Kenya: Preliminary results and evidence of dilution of the indigenous Red Maasai. Proceedings of the 9th World Congress on Genetics Applied to Livestock Production, Leipzig Germany 1-6th August 2010.
  • Kwallah A.B., Muigai A.W.T., Mburu D., Mwai O and Imbuga M. (2007) Genetic diversity of the Kenyan sheep - current status. National Science and Agricultural Conference, July 21-23, Kigali, Rwanda.
  • Mburu D., Fan , Vahidi S.M.F., Faruque M.O., Binh N.T., Nanayakkara H.L.V., Zein M.S.A. Mahmood S., Li K., Thuy L.T., Silva L.P., Muladno M., Naqvi A., Mirhoseinie S.Z., Alshaikh M.A., Kibogo H.G., Ajmone-Marsan P., Boettcher P.J., Garcia J.F., Hanotte O. & Jianlin H. (2006) Genetic diversity and population structure of indigenous goats from Asia. XIIth Asian Australasian Association of Animal Production Societies, September 18th-22nd, Busan, South Korea.
  • Aswani B.O., Kijas J., Limo M., Hannote O. & Mburu D. (2006) Analysis of genetic diversity and relationships of the African male sheep using two Y chromosome specific markers. Proceedings of the 30th International Conference on Animal Genetics, August 20th-25th, 2006 Porto Seguro, Bahia State, Brazil.
  • Alimohammadian M., Anderson S., Brass A., Gibson, J.P., Hulme H., Iraqi, F.A., Kemp, S.J., Mburu D., Naessens J. & Noyes H.A. (2006). Identification of gene networks associated with anaemia caused by Trypanosoma congolense. Genomes to Systems Conference, March 22nd-24th, Manchester International Convention Centre, Manchester, UK.
  • Koudandé D., Dossou-Gbété G., Mujibi F., Kibogo H., Mburu D., Mensah G.A., Hanotte O. & van Arendonk  J.A.M (2005). Cattle genetic diversity assessment in the coastal regions of the BIGHT of Benin. The Role of Biotechnology in Animal Agriculture to Address Poverty in Africa: Opportunities and Challenges. 4th All Africa Conference on Animal Agriculture, September 20th-24th, Arusha, Tanzania.
  • Mburu D.N. & Hanotte O. (2005). Comparative genetic analysis of molecular diversity of African cattle. FAO Conference on the Role of Biotechnology for the Characterization and Conservation of Crop, Forestry, Animal and Fishery Genetic Resources, March 5th-7th, Turin, Italy.
  • Mburu D.N., Naessens J., Noyes H., Kemp S., Gibson J. & Iraqi F. (2004). Development of pathology in A/J, C57BL/6 and BALB/c mice following Trypanosoma congolense 18th International Mouse Genome Conference, October 17th-22nd, Seattle, USA.
  • Naessens J., Mburu D.N., Noyes H., Kemp S., Gibson J. & Iraqi F. (2004). The capacity to control of anemia development and parasitaemia growth is under different genetic mechanisms in African murine trypanosomosis. 18th International Mouse Genome Conference, October 17th-22nd, Seattle, USA.
  • Agola L.E., Mburu D.N., Dejong R.J., Mungai B.N., Muluvi G.M., Njagi E.N.M., Loker E.S. & Mkoji G.M. (2004). Analysis of genetic diversity in Kenyan populations of Schistosoma mansoni using microsatellite markers. 25th African Health Sciences Congress, October 4th-8th, Nairobi, Kenya.
  • Kierstein G., Mburu D.N., Muigai A.W.T., Jianlin H., Rege J.E.O. & Hanotte O. (2003). Understanding the genetic diversity of livestock: an essential step for the management and improvement of farmers’ resources. In: Deutscher Tropentag. (Eds Wollny C., Deininger A., Bhandari N., Maas B., Manig W. & Muuss U.), Göttingen, Germany, 8th-10th October, 2003.
  • Iraqi F.A., Noyes H., Mburu D., Wade C., Kemp S. & Gibson J. (2003). Multiple approaches for dissecting quantitative trait loci and cloning the underlying genes. Complex Trait Consortium Meeting, July 1st-3rd, Oxford, UK.
  • Mburu D.N., Ochieng J.W., Jianlin H., Kaufmann B., Kuria S.G., Rege J.E.O. & Hanotte O. (2001). Genetic diversity and relationship of indigenous Kenyan camel breeds: preliminary results. In: The Challenges of Drought to Livestock Production in Kenya (Eds Abdulrazak S.A., Mwangi D. & Mukisira E.A.), pp 151-154. Proceedings of the Animal Production Society of Kenya. Symposium held at Egerton University, Njoro, March 7th-8th. APSK, Nairobi, Kenya.
  • Mburu D., Otsyula M., Graham B. & Spearman P. (1999). Molecular cloning and sequencing of CCR5 molecules from three East African simian species. In: Sustainable Research in Biomedicine, Health and Conservation. Proceedings of the 14th IPR Annual Scientific Conference, 10th–11th November 1999, Nairobi, Kenya.
  • Mburu D., Otsyula M., Graham B. & Spearman P. (1999). Differential utilization of CCR5 molecules from three East African simian species by the HIV-envelope glycoprotein. In: Sustainable Research in Biomedicine, Health and Conservation. Proceedings of the 14th IPR Annual Scientific Conference, 10th–11th November 1999, Nairobi, Kenya.

Networks/Collaboration

  • International Livestock Research Institute: Distribution of ticks and the risk of tick-borne diseases in irrigated areas in different ecological zone of Kajiado and Tana River Counties, Kenya.
  • Kenya Marine and Fisheries Research iInstitute: Biogeochemical effects of sewage pollution on the mollusc Nerita polita.
  • Kenya Bureau of Standards: Mapping the quality of Kenyan honey.
  • Kenya Agricultural and Livestock Research Organization: Prevalence, impact and control of aflatoxicosis in Kenyan reared broiler chicken.
  • International Centre for Insect Physiology and Ecology: Genetic diversity of Anaplasma gambiae and Plasmodium surface protein genes.
  • Kenya Medical Research Institute: Assessment of the genetic Diversity and schistosome burden in a rural community following a school-based mass drug administration in Mwea, Central Kenya.