Title/Qualifications: Dr. PhD
Department/Unit/Section: Microbiology
Contact Address:P.O. Box 43844 00100 Nairobi
Telephone:
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Publications

• Nyamache A.K, S.A. Khamadi and M. O Oyaro. Genetic diversity, distribution and co-infections of Hepatitis B virus, Hepatitis C virus, and HIV-1 in Africa: A systemic review. J. of Virology.in press
• Nyamache A.K and F. Nindo: Evolutionary history and phylodynamics of HIV-1 subtype A and its epidemics in Kenya. In press
• Nyamache AK, A.W Muigai, SA Khamadi. Circulating Trends of non B HIV type 1 subtypes among Kenyan individuals. Journal of AIDS Research and Human Retroviruses 2013, 29(2): 400-403
• Nyamache A.K, Muigai A.W, Khamadi S.A.: Profile of HIV-1 Co-Receptor Tropism among Kenyan patients from 2009 to 2010. Journal of AIDS Research and Human Retroviruses. 2013; 29, 8, 1105-1109
• Nyamache A.K, A. Muigai, S.A. Khamadi: Phylogenetic analysis of the envelope HIV-1 type 1 isolates among Kenyan cohort. African Journal of heath and therapeutics 2012; 1:4:1
• Nyamache A.K, Anne. Muigai, Zipporah Nganga Samoel Ashimosi Khamadi: HIV-1 genetic diversity and naturally occurring polymorphisms in HIV-1 Kenyan isolates Integrase gene: Implications for integrase inhibitors: Journal of AIDS Research and Human Retroviruses: Vol 28: 933-936. 2012
• Nyamache K.A, Waihenya, Ng’ang’a Z.W, Muigai A.W, Khamadi .A.S, Reverse Transcriptase Inhibitors Drug Resistance Mutations in Drug-Naive HIV Type 1 positive Kenyan Individuals: East Africa Medical Journal 2011; 88:4:261-265
• Nyamache A.K: Evaluation of HIV-1 evolution of HIV-1 evolution and its role in development of antiretroviral drug resistance, in Nairobi Cohort. 2011 PhD thesis
• Nyamache A.K, A. Muigai, Z. Nganga, S.A. Khamadi: HIV-1 genetic diversity and naturally occurring polymorphisms in HIV-1 Kenyan isolates Integrase gene: Implications for integrase inhibitors: African Journal of health sciences 2011: Vol 19:30-4 (suppl) 1.011 2011
• Nyamache A.K and S.A. Khamadi: HIV-1 drug resistance among untreated patients in Kenya: Current status. Journal of Applied Bioscience 2011; 8: 43:2958-2966
• Nyamache A.K P. Ochola R, Khamadi S.A isolation and antimicrobial susceptibility testing of Escherichia coli causing urinary tract infections. J. Applied Bioscience2009; 22:Vol 27:1320-1325,2009
• Nyamache K.A, Waihenya R, Khamadi S.A. HIV genetic diversity among drug naïve populations of Nairobi Kenya Journal of Retrovirology 2009; 6 (Suppl 3):P371 doi:10.1186/1742-4690-6-S3-P371
• Anthony Kebira Nyamache: Extent of drug resistance mutations among HIV-1 positive drug-naive populations: 2008 Msc thesis

Co-authored

• John Kibet Kirui, John Maingi, Collins Ogari, A. K. Nyamache. Prevalence of Multidrug Resistant Tuberculosis among Previously Treated TB Patients in Nairobi County, Kenya. BMC Infectious disease. Under review. 2019
• Collins Otieno Ogari, A.K Nyamache, J. Nonoh and E. Amukoye. Prevalence and detection of drug resistant mutations in Mycobacterium tuberculosis among drug naïve patients in Nairobi, Kenya. BMC Infectious Diseases (2019) 19:279
• Lydia Mali Langata, John, John M. Maingi, Harry Asena Musonye, John Kiiru, A.K Nyamache. Antimicrobial Resistance Genes in Salmonella and Escherichia coli Isolates from Chicken Droppings in Nairobi, Kenya. BMC Res Notes (2019) 12:22
• Koigi P, Musa Otieno, Caroline Ngugi and A. K. Nyamache. HIV-1 genetic diversity and among drug experienced patients in Nairobi, Kenya. AIDS and Human Retroviruses Journal under review 2018
• H.R. Opinde, A.K Nyamache, G. W Gatheri.(2018).Antimicrobial activity, qualitative phytochemical composition of crude extracts from medicinal plants against selected enteric bacterialpathogens, Candida albicans. Bioteknologi 15(1)1-12
• Regina Ntabo1, Anthony Kebira Nyamache , Wilber Lwande , James Kabii Rechab Sylvester Odhiambo James Antimicrobial activity and GC-MS analysis of bacterial endophyte GD4SAL isolated from the mangrove, Sonneratia alba. BMC Microbiology Journal .
• Regina Ntabo, Anthony Kebira Nyamache , Wilber Lwande , James Kabii and James Nonoh. Enzymatic activity of endophytic bacterial isolates from selected mangrove plants in Kenya. Accepted and a head of print The Open Microbiology Journal Vol 12;354-363
• Lem E. Abongwa, Fokunang C, A. K. Nyamache, P. Okemo, L. A. Tchapda, Yengo Clauvis,Takou Désire. Fokam J, Aubain Nanfack, Teto G., and J. N. Torimiro. Clinically Important Mutations in HIV-1 Protease and Reverse Transcriptase Regions Associated to Resistance to Antiretroviral First Line Regimen in Cameroon" PLos One Under review
• L.E Abongwa, A. K. Nyamache, Fokunang C, J.T. D. Larissa, N. Loveline, P. Okemo and G. Nchinda. Cytokines associated with antiretroviral induced hepatotoxicity in people infected with the human immunodeficiency virus type 1 in the northwest region of Cameroon for publication in “International J. of Med. Resea and Pharmaceutical Sciences, 5:3: DOI- 10.5281/zenodo.1206028
• Opinde HR, AK Nyamache, Gw Gatheri -, 2018.Antimicrobial activity, qualitative phytochemical composition of crude extracts from medicinal plants against selected enteric bacterial pathogens, Candida albicans. Journal of Bioteknologi Biotechnological Studies, 15(1), 1-12
• Esther Wanjiku Muitta , J. Muhoho, A. K. Nyamache, T. Were, Retrospective evaluation of pre cervical cancer symptom screening and management in Rift Valley Provincial General Hospital (Nakuru County) MAY 201, The East and Central Africa Medical Journal. Under Review
• G.Gachara; A.K. Nyamache; G.J.B. Gnonlonfin; J. Harvey; J. Wainaina; I. Wanjuki, and R. Skilton. "Genetic diversity of Aspergillus flavus and occurrence of aflatoxin contamination in stored maize across three agro-ecological zones in Kenya." Agric & Food Secur (2018) 7:52
• Mutinda J,; A. K. Nyamache; M. John. Antimicrobial susceptibility patterns of bacteria associated with upper respiratory tract infections in Kitui, Kenya. Ethiop Med J, 2017, Vol 55, No.2
• Irene S. Nyamwaka, Anthony K. Nyamache and John M. Maingi. Microfungi Associated with Sun Dried Rastrineobola argentea Sold in Gucha South District in Kenya. Microbiology Research Journal International. 19(3): 1-8, 2017;
• Abongwa, L.E., Nyamache, A.K., Akono, N., Sunjo, S., Nange, V., Balan, H., Charles, F., Okemo, P. and Torimiro, (2017). Hepatotoxicity and anaemia co-morbidity in treated aids patients in fundong sub division in the northwest region of Cameroon. Microbiology Research Journal 18(5): 1-10, 2017
• Hesbon Omwoyo Nyang 'au John Maingi Anthony Kebira Nyamache. The efficacy of some medicinal plants used locally within Transmara west, Narok County, Kenya against selected Enterobacteria and Candida. Journal of Pharmacy and Biological Sciences.12:1;1; 115-122, 2017
• Mabeya SN, C Ngugi, AK Nyamache, R Lihana. Prevalence of Hepatitis B virus infections among HIV infected individuals in Nairobi, Kenya. East African Medical Journal 93 (6), 221-225
• Usagi M.B., G.Ab. Odilla, J. M. Maingi, A.K. Nyamache. Isolation, Identification and Determination of the Prevalence of Mycobacterium tuberculosis Complex among People Living with HIV in Kisumu County, Kenya. Science Journal of Public Health. 2016: 4; 4: 359-365
• Rachuonyo HO, Gatheri GW, Ogola PE, Arika WM, Wambani JR, Kamau DN, AK Nyamache. In vitro Antifungal activity of leaf extracts from Aloe secundiflora, Bulbine frutescens, Vernonia lasiopus and Tagetes minuta against Candida albicans. J. Med Aromat Plants 2016, 5:2
• Mutuiri S.P. M., H.L. Kutima , L.M. Mwapagha, J.K. Munyao, A.K. Nyamache, I.Wanjiru S.A Khamadi. RANTES gene polymorphism (-(403G>A and 28C>C) associated with HIV-1 infections in Kenyan population. Disease Markers 2016
• Wabale M Kilongosi, Valentine Budambula, Raphael Lihana, Francis O. Musumba, A. K. Nyamache, Nancy L.M. Budambula, Aabid A. Ahmed, Collins Ouma, and Tom Were. Hepatitis B Virus Sero-profiles and Genotypes in HIV-1 Infected and Uninfected Injection and Non-Injection Drug Users from Coastal Kenya. BMC infectious diseases 15 (1), 299
• Jedidah Ndunge Moto, John Muthini Maingi, A. K. Nyamache. Prevalence of Tinea Capitis in school going children from Mathare, Informal Settlement in Nairobi, Kenya. BMC Research notes review 2015 8:274.
• Paul Njenga Waithaka, J. Maingi, A. K Nyamache. Development of Predictors algorithm for Mortality, Drop Out and Immuno-virologic outcomes among HIV-1 infected Intravenous Drug Users receiving highly active antiretroviral therapy in Malindi, Kenya. Scientific Journal of Microbiology (2014) 3(12) 118-125
• Koigi P, Musa Otieno, Caroline Ngugi and A. K. Nyamache. Genotyping of HIV type 1 drug resistance among patients with immunological failure to first and second line antiretroviral therapy in Kenyan subjects. Journal BMC Res Notes. 2014;7(1):890
• Paul Njenga Waithaka, J. Maingi, A. K Nyamache Microbial contamination of environmental, food and treated water samples in Nakuru North Sub-county, Kenya Intern. J. of Microbiology and Allied Sciences. 2014 Dec, 1(2):78-91
• Paul Njenga Waithaka, John Muthini Maingi, A. K. Nyamache. Physico-chemical and Salmonella isolates in community taps and river Kandutura in Nakuru North Sub-county, Kenya. Under review. Intern. J. of Microbiology and Epidemiological Research, Nov 2014, 2(4), 29-37,
• Schifra Uwamungu, Florence Masaisa, Sarah Kaggia Njoki, A. K. Nyamache. Coagulation factors level in fresh frozen plasma in Rwanda. East African Medical J. 91:3 2014
• Zackary Maingi and A. K. Nyamache.. Seroprevalence of Cytomegalo Virus (CMV) among pregnant women in Thika, Kenya. BMC. Research notes Journal 2014, 7:794 doi:10.1186/1756-0500-7-794
• Osborn Yamakhakha Khasabuli and A. K. Nyamache. Isolation, characterization and primary screening of soil actinomycetes from Kenyatta University arboretum grounds for antibacterial activities. J. of Applied Biosciences. 2014 74:6072– 6079
• Caroline Nyawira Wahome, Paul Owuor Okemo and A. K. Nyamache. Microbial quality and Antibiotic Resistant Bacterial Pathogens Isolated from Groundwater Used by Residents of Ongata Rongai, Kajiado North County, Kenya. Intern. J. Biological and Biochemical Sciences 2014: 8: (1): 134-143 2014.
• Omari Amuka, Paul Okemo, Alex Machocho, Paul Mbugua, Eliud NM Njagi, and A.K Nyamache. Part 1The Role of Phytomedicine in the Challenges of Emerging, Re-Emerging Diseases; and Pathogens Resistance to Antibiotics. Intern. J. of Herbal medicine 2013: 1(4)77-84
• Omari Amuka, Paul Okemo, Alex Machocho, Paul Mbugua, Eliud NM Njagi, and A.K Nyamache. Part 2The Role of Phytomedicine in the Challenges of Emerging, Re-Emerging Diseases; and Pathogens Resistance to Antibiotics. Intern. J. of Herbal medicine 2013: 1 (4): 92-101
• Omari Amuka, Paul Okemo, Alex Machocho, Paul Mbugua, Eliud NM Njagi, and A.K Nyamache. Part 3The Role of Phytomedicine in the Challenges of Emerging, Re-Emerging Diseases; and Pathogens Resistance to Antibiotics. Intern. J. of Herbal medicine 2013: 1 (4) 102-106
• Erick M Bosire, A.K Nyamache, Michael M Gicheru, Raphael W Lihana,Vincent Okoth and Samoel A Khamadi. Population specific reference ranges of CD3, CD4 and CD8 lymphocyte subsets among healthy Kenyans. AIDS Res Ther. 2013 :7;10(1):24.
• Beatrice Mukami Muriuki, Michael Muita Gicheru, Dorcas Wachira, A. K. Nyamache and Samoel Ashimosi Khamadi. Prevalence of hepatitis B and C viral co-infections among HIV-1 infected individuals in Nairobi, Kenya. BMC Research notes 2013, 6:363 doi:10.1186/1756-0500-6-363

Conference abstracts and workshops

• Abongwa, L.E., Nyamache, A.K., Akono, N., Sunjo, S., Nange, V., Balan, H., Charles, F., Okemo, P. and J. Torimiro, ( 2018). HIV drug resistance profile to first line antiretroviral therapy regimen in naïve patients in the Northwest region (NWR) of Cameroon. Poster. AAAMR congress ( http://africaamr.org/) on 26-28 February 2018 in Bamako, Mali.
• Abongwa, L.E, A.KNyamache, Fokunang C, P. Okemo , Laure AT, Yengo C Takou D , J.N Torimiro. HIV drug resistance profile to first line antiretroviral therapy regimen in naïve patients in the northwest region (NWR) of Cameroon. 34th Annual Clinical Virology Symposium to be held from May 6-9, 2018 in West Palm Beach, Florida.
• Abongwa, L.E, A.K Nyamache, Fokunang C, P. Okemo , Laure AT, Yengo C Takou D , J.N Torimiro. “Cytokines associated with antiretroviral induced hepatotoxicity in people infected with the human immunodeficiency virus type 1 in the Northwest region of Cameroon” 34th Annual Clinical Virology Symposium to be held from May 6-9, 2018 in West Palm Beach, Florida.
• Abongwa, L.E., Nyamache, A.K., Akono, N., Sunjo, S., Nange, V., Balan, H., Charles, F., Okemo, P. and Torimiro, ( 2017). Hepatotoxicity and anaemia co-morbidity in treated aids patients in fundong sub division in the northwest region of cameroon. Sex Transm Infect Volume 93, Issue Suppl 2: A79-A79

• Abongwa, L.E., Nyamache, A.K., Akono, N., Sunjo, S., Nange, V., Balan, H., Charles, F., Okemo, P. and Torimiro, ( 2017). Hepatotoxicity and anaemia co-morbidity in treated aids patients in fundong sub division in the northwest region of cameroon. Sex Transm Infect Volume 93, Issue Suppl 2: A79-A79

• Koigi P, Otieno M, C. Ngugi and A. K. Nyamache. Genotyping of HIV type 1 drug resistance among patients with immunological failure to first and second line antiretroviral therapy in Kenyan. The 3rd Medical and veterinary virus Research in Kenya (MVVRK ) symposium 2014. Hilton Hotel, Nairobi Kenya.

• G.Gachara; A.K. Nyamache; G.J.B. Gnonlonfin; J. Harvey; J. Wainaina; I. Wanjuki, and R. Skilton. Post-harvest fungi diversity and aflatoxin contamination in stored maize in Eastern and Western Kenya. Poster presentation.19th International Scientific Conference, 11th -13th September,2013.Nairobi,Kenya.
• G.Gachara; A.K. Nyamache; G.J.B. Gnonlonfin; J. Harvey; J. Wainaina; I. Wanjuki, and R. Skilton. Post-harvest fungi diversity and aflatoxin contamination in stored maize in Eastern and Western Kenya.Oral presentation.1st International One Health Central and Eastern Africa (OHCEA) Conference.23rd- 27th September, 2013.Addis Ababa, Ethiopia.
• G.Gachara; A.K. Nyamache; G.J.B. Gnonlonfin; J. Harvey; J. Wainaina; I. Wanjuki, and R. Skilton Occurrence and distribution of aflatoxin contamination in stored maize across three Agro-ecological zones in Kenya. 3rd Kenya International Lung Health Conference. 2nd- 5th October, 2013. Nairobi, Kenya.
• G.Gachara; A.K. Nyamache, G.J.B. Gnonlonfin; J. Harvey; J. Wainaina, R. Skilton . Aflatons threat to Kenya Maize consumptions, case studies of selected Kenyan counties study. 4th Biennal NMK conference 6th - 8th Nov 2013, Tanzania
• Nyamache A.K, Z. Nganga, A. Muigai, S.A. Khamadi: High prevalence of primary Enfuvirtide (ENF) resistance-associated mutations in HIV-1-infected patients in Nairobi. Submitted for ICASA conference 2013 Cape Town SA.
• Nyamache A.K, A. Muigai, S.A. Khamadi: Phylogenetic analysis of the envelope HIV-1 type 1 isolates among Kenyan cohort. Oral: The 2nd Medical and veterinary virus Research in Kenya (MVVRK) symposium. Panafric Hotel, Nairobi Kenya
• Nyamache A.K, Z. Nganga, A. Muigai, S.A. Khamadi: HIV-1 co-receptor tropism in Nairobi cohort and its implication to antiretroviral therapy in Kenya: Oral Abstract No 1661 16th International AIDS and STDs Conference, 4-8th December 2011, Adisa Ababa Ethiopia.
• Nyamache A.K, Z. Nganga, A. Muigai, S.A. Khamadi: HIV Type 1 Genetic Diversity in Nairobi cohort, its implications on vaccine design and drug resistance abstract No. 056: ITROMID JKUAT, Nairobi, Kenya 18-19th May 2011, conference.
• Nyamache A.K, Z. Nganga, A. Muigai, S.A. Khamadi: HIV-1 genetic diversity and naturally occurring polymorphisms in HIV-1 Kenyan isolates Integrase gene: Implications for integrase inhibitors 1st annual KEMRI scientific conference, KEMRI HQ Nairobi 9-11th Feb 2011.
• Nyamache A.K, Z. Nganga, A. Muigai, S.A. Khamadi: HIV-1 genetic diversity and viral tropism among Kenyan individuals: 1st East Africa regional Scientific conference, Kenyatta University, Kenya August 2010
• Nyamache A.K, Z. Nganga, A. Muigai, S.A. Khamadi :HIV-1 Genetic diversity and drug resistance among cohort of women in Nairobi, Kenya: International Microbicides-bridges in HIV prevention conference 21-25th May 2010 Pittsburgh, Pennsylvania, USA