Department of Chemistry
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P. O. Box 43844-00100,

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Bioassay guided isolation and characterization of natural products with emphasis on antimicrobials, antimalarial, anticancer and antidiabetic, synthesis and semi synthesis of natural products, Essential Oils; Extraction and Chemical Profile Analysis and determination of their pharmacological activities; Ethno-botanical Management of Brown Ear tick Rhipicephalus appendiculatus. Application of chemical ecology in the control of ticks and tsetse flies through structural activity studies of potential repellents, Water remediation studies using agricultural wastes as adsorbents; studies of soil, plant nutrients and adsorption chemistry in pursuit of sustainable agriculture practices; Use of modified adsorbents in agricultural practices to improve food security; Isolation and characterization of various mycotoxin; Management of Fungal metabolites (Mycotoxins and Ochratoxins) using ethnobotanicals

Mentorship Statement: Dr Margaret Nganga is passionate about mentorship of young men and men. My mentorship style is empowerment-oriented, culturally sensitive, holistic, compassionate and excellence driven. I have been a mentor for over 20 years in the world of academia /research for both undergraduate and graduate students. I have extensive experience in mentorship for the youth especially for the girls in STEM. I spearhead mentorship program as a Chairperson of Board of Management of St Alexis Ruchu girls with over 1000 girls and as a board member of OLR Mugoiri Girls high school board of management in-charge of academics. I have acquired training and coaching in Transformational Leadership from Africa Center for Transformative and Inclusive Leadership (ACTIL). I am extremely proud of the diversity and large number of the graduate students whom I have mentored and of their impressive research and career success.

Research/ Projects

  1. Ethno botanical Management of Brown Ear tick Rhipicephalus appendiculatus
  2. Essential Oils; Extraction and Chemical Profile Analysis, Determination of their Antimicrobial Activity.
  3. Isolation and characterization of antimalarial compounds from medicinal plants used in Kenya.
  4. Aflatoxins in Maize and Major Cereals, in locally brewed beverages and their raw materials, their Residue Levels in Human Blood and their Impact on the Kenya Agro- Based Economy.

On going Projects

  1. Tick repellents chemical constituents against Rhipicephalus appendiculatus
  2. Structural-activity studies of potential menthane-diol tick repellents
  3. Development of simple on-host behavioural manipulation tactics of controlling r. Appendiculatus, the vector of the cattle disease East Coast Fever.


  1. Margaret W. Kariuki, Ahmed Hassanali, and Margaret M. Ng’ang’a (2022). Nanoencapsulation of 4-propylguaiacol in β-cyclodextrin, ethyl cellulose, and polyvinylpyrrolidone. Journal of Chemistry; Volume 2022 |Article ID 6590850 |

  2. Juliet Ochola, Laura Cortada, Onesmus Mwaura1, Meklit Tariku, Shawn A. Christensen, Margaret Ng’ang’a, Ahmed Hassanali, Tahira Pirzada, Saad Khan, Lokendra Pal, Reny Mathew, Dick Guenther, Eric Davis, Tim Sit, Danny, Charles Opperman, and Baldwyn Torto (2022). Wrap-and-plant technology to manage sustainably potato cyst nematodes in East Africa. Nature Sustainability, VOLMay 2022 425–433.

  3. Ruth Kihika-Opanda, David P. Tchouassi, Margaret M. Ng’ang’a, John J. Beck, and Baldwyn Torto Chemo-Ecological Insights into the Use of the Non-Host Plant Vegetable Black-Jack to Protect Two Susceptible Solanaceous Crops from Root-Knot Nematode Parasitism. J. Agric. Food Chem. 2022, 70, 22, 6658–6669. Publication Date May 25, 2022

  4. Wairagu, N. W., Wachira, B. M., Githiomi, J. K., Oduor, N., & Ng’ang’a, M. M. (2022). Repellency and Toxicity of Selected Fractions, Identified Compounds and Blends of Commiphora africana Resin against bedbugs. Natural Product Communications, 17(6), 1934578X221106898.

  5. Benson Wachira, Joy M. Kabaka, Sylvance O. Okoth Margaret Nganga, Robert Changasi, Patrick Obore, Benard Ochieng’, Grace A. Murilla, Ahmed Hassanali (2021). Characterization of a composite with enhanced attraction to savannah tsetse flies from constituents or analogues of tsetse refractory waterbuck (Kobus defassa) body odor'. Plos Neglected Tropical Disease. June 1, 2021

  6. Margaret Nganga, Mary Wanjiku Nyangi, Elizabeth Mumbi Kigondu, Beatrice Irungu, Anthony Gachanja; et al. (2021), Integrity, Use and Care of Long-Lasting Insecticidal Nets in Kirinyaga County, Kenya BMC Public Health BMC Public Health 21:856

  7. Mary Juliet Ochola, Laura Cortada, Margaret Ng’ang’a, Ahmed Hassanali, Danny Coyne and Baldwyn Torto (2020). Mediation of Potato–Potato Cyst Nematode, G. rostochiensis Interaction by Specific Root Exudate Compounds. Frontier Plant Science., 10 June, 2020

  8. Juliet Ochola, Danny Coyne, Laura Cortada, Solveig Haukeland, Margaret Ng'ang'a, Ahmed Hassanali, Charles Opperman and Baldwyn Torto (2020). Cyst nematode bio-communication with plants: implications for novel management approach. Pest Management Science DOI 10.1002/ps.6105

  9. Ruth Kihika, David P. Tchouassi, Margaret M. Ng’ang’a, David R. Hall, John J. Beck, and Baldwyn Torto (2020). Compounds Associated with Infection by the Root-Knot Nematode, Meloidogyne javanica, Influence the Ability of Infective Juveniles to Recognize Host Plants. J. Agric. Food Chem 68 (34), 9100-9109.

  10. David O. Ywaya, Michael A. Birkett, John A. Pickett, John B. Ochola, Lwande, Wilber, Benson M. Wachira, Ahmed Hassanali and Margaret M. Ng’ang’a (2020). Repellency and Composition of Essential Oils of Selected Ethnobotanical Plants Used in Wstern Kenya against Bites of Anopheles gambiae Sensu Stricto. Journal of Essential Oil-Bearing Plants, 23:3, 432-441, DOI: 10.1080/0972060X.2020.1780954.

  11. Ephantus G. Ndirangu1, Sylvia A. Opiyo and Margaret W. Ng’ang’a (2020). Chemical composition and repellency of Nigella sativa L. seed essential oil against Anopheles gambiae sensu stricto. Trends in Phytochemical Research (TPR) 4(2) 2020 77-84.

  12. Mulwa, P., Njue, W., and Ng’ang’a, M (2020) Assessment of L-Citrulline, L-Arginine and L Glutamic Acid Content in Selected Fruits, Vegetables, Seeds, and Nuts Sold in Markets in Nairobi City County, Kenya. European Journal of Agriculture and Food Sciences, 2(5). https: // 10.24018/ ejfood.2020.2.5

  13. Benson M. Wachira, Joy M. Kabaka, Paul O. Mireji, Sylvance O. Okoth, Margaret M. Ng'ang'a, Grace A. Murilla, Ahmed Hassanali (2020). Blending studies with selected waterbuck odor constituents or analogues in the development of a potent repellent blend against savannah tsetse. Acta Tropica 211 (2020) 105597.

  14. Lilian C. Koech, Beatrice N. Irungu, Margaret M. Ng’ang’a, Joyce M. Ondicho, and Lucia K. Keter (2020). Quality and Brands of Amoxicillin Formulations in Nairobi, Kenya. Hindawi BioMed Research International, Volume 2020, Article ID 7091278, 14 pages

  15. Ngari Ann G, Omolo Maurice O, Tarus Paul K, Ng’ang’a Margaret M, and Hassanali Ahmed. Chemical compositions of smoke volatiles of some Kenyan Ocimum species. Journal of Pharmacognosy and Phytochemistry 2020; 9(1): 1871-1879.

  16. Kibiwott Jepkorir Scolar, Ng’ang’a Mwihaki Margaret, and Ngugi Mathew Pier 2020. In vitro antioxidant activities of Carissa edulis Vahl and Caesalpinia volkensii Harms extracts. African Journal of Biochemistry Research Received: 04 February 2020 Accepted: 19 March 2020 (in press)

  17. Peter Muchoki Githinji, Jeremiah Waweru Gathirwa, Margaret Mwihaki Ng’ang’a, Alex King’ori Machocho (2020). Triterpenoids from Grewia plagiophylla K. Schum. Pharmacognosy Communication. 2020 ;10 (3) 130 -1 33.

  18. Peter Muchoki Githinji, Jeremiah Waweru Gathirwa, Margret Mwihaki Ng’ang’a, Alex King’ori Machocho, (2020). Triterpenoids from Grewia plagiophylla. Pharmacognosy Communication. 2020;10 (2):102-107.

  19. Constantine Kameti, Dr. Henry Mwangi, Dr. Margaret Ng’ang’a (2020). In Vitro Anticancer, Antimicrobial and Antioxidant Screening of Compounds from Ricinus Communis Linn: A Review. World Journal of Research and Review (WJRR) ISSN: 2455-3956, Volume-11, Issue-5, November 2020 Pages 04-11

  20. F Maingi, M Mwihaki Ng'ang'a, HM Mbuvi, H Mwangi, (2019) Clay-Rice Husk Ash based Geopolymers for Remediation of Pb (II) and Cd (II) from Wastewater, Egerton Journal of Science and Technology 17 (1-139), 15-28.

  21. Josephine E. Mwihaki, Harun Mbuvi, Margaret Mwihaki, (2019) Derivatization of Papyrus Reeds for Use as a Super Absorbance Mulch Substrate, International Journal of Science and Research (IJSR) 8 (3), 1353 – 1363.

  22. Ngari Ann G, Omolo Maurice V, Tarus Paul K, Ng’ang’a Margaret M, and Hassanali Ahmed (2019). Chemical compositions of fresh volatiles aromas of some Kenyan Ocimum species. Journal of Pharmacognosy and Phytochemistry; 8(6): 201-208.

  23. Ngari Ann G, Omolo Maurice V, Tarus Paul K, Ng’ang’a Margaret M and Hassanali Ahmed (2019) Chemical compositions of essential oils of some Kenyan Ocimum species. American Journal of Essential Oils and Natural Products; 7(3): 17-26.

  24. T. J. Shikorire G. O. Asudi, M. M. Ng’ang’a, G. Kirubi & A. Hassanali (2019). Analysis of emission profiles from charcoal produced from selected tree species by different pyrolysis methods. International Journal of Environmental Science and Technology 16, 5995-6004.

  25. S. N. Nyamu, L. Ombaka, E Masika and M. Ng’ang’a (2019), One pot microwave assisted synthesis of size dependent glutathione capped spherical silver nanoparticles suitable for materials with antibacterial properties. Interdisciplinary Nanomedicine 4 (3) 86-94.

  26. F.M. Maingi, M. M. Ng’ang’a, H. Mwangi, H. M. Mbuvi and A. Abdulhameed (2018). Thermodynamic, Kinetic and Equilibrium Studies of Pb (II) ions adsorption using ordinary clay/rice husk ash based geopolymers. IOSR Journal of Applied Chemistry (IOSR-JAC) e-ISSN: 2278-5736.Volume 11, Issue 8 Ver. I (August. 2018), PP 46-54.

  27. Samuel N. Nyamu, Lucy Ombaka, Eric Masika, and Margaret Ng’ang’a (2018). Antimicrobial Photodynamic Activity of Phthalocyanine Derivatives. Advances in Chemistry: Article ID 2598062:

  28. Margaret W. Kariuki, Ahmed Hassanali, Margaret M Nganga (2018). Characterization of cattle anal oduor constituents associated with the repellency of Rhipicephalus appendiculatus. Experimental and Applied Acarology 76: 221-227.

  29. M. Maingi, H. M. Mbuvi, M. M. Ng’ang’a, H. Mwangi (2018). Adsorption of Cadmium Ions on Geopolymers Derived from Ordinary Clay and Rice Husk Ash International Journal of Materials and Chemistry, 8(1): 1-9. DOI: 10.5923/j.ijmc.20180801.01.

  30. Hannah N. Wamakima, Peter G. Kirira, Margaret M. Nganga, Winnie R. Gimode, Brendon Naicker, Matshawendile Tukulula and Francis W. Muregi (2018). Synthesis and antiplasmodial Evaluation of A new trioxaquine. European Journal of Pharmaceutical and Medical Research, 5(5), 26-34 ISSN 2394-3211

  31. F. M. Maingi, H. M. Mbuvi, M. M. Ng’ang’a (2018). Aluminophosphates Derived from Tea Leaves and Pumpkin Seeds Ashes Adsorb Lead Ions from Contaminate. Water Frontiers in Science 2018, 8(1): 1-10. DOI: 10.5923/j.fs.20180801.

  32. Margaret W Kariuki, Ahmed Hassanali, Margaret M Ng’ang (2019). Structure-activity Studies on Analogues of 4-methylguaiacol, a Cattle Anal Odour Constituent Repellent to the Brown Ear Tick (Rhipicephalus Appendiculatus. Acta Tropica; 194:78-81 PMID: 30922799. DOI: 10.1016/j.actatropica.2019.03.025.


  33. Ruth Kihika, Lucy K. Murungi, Danny Coyne, Margaret Ng’ang’a, Ahmed Hassanali, Peter E. A. Teal & Baldwyn Torto (2017). Parasitic nematode Meloidogyne incognita interactions with different Capsicum annum cultivars reveal the chemical constituents modulating root herbivory. Scientific Reports 7: 2903 DOI:10.1038 s41598-017-02379-8.

  34. Daniel Muvengei, Haron Mbuvi, Margaret Ng’ang’a (2017). Removal of Pb2+ and Cd2+ Ions, colour and turbidity from water using carbon and ash derived from maize cobs. IOSR Journal of Applied Chemistry.Volume 10, Issue 6 PP 58-68

  35. Shylock O. Onduso, Margaret M. Nganga, Waceke Wanjohi, Ahmed Hassanali Determination of pyrrolizidine alkaloids levels in Symphytum asperum. Biofarmasi J Nat Prod Biochem Volume 15, Number 2, August 2017 E-ISSN: 2580-2550 Pages: 65-78 DOI: 10.13057/biofar/f150203.

  36.  M. Maingi, H. M. Mbuvi, M. M. Ng’ang’a, H. Mwangi (2017). Adsorption Kinetics and Isotherms of Methylene Blue by Geopolymers Derived from Common Clay and Rice Husk Ash Physical Chemistry, 7(4): 87-97. DOI: 10.5923/j.pc.20170704.02.

  37. N. M. Ombuna, A. K. Machocho, M. M. Ng’ang’a, G. K. Keru, A. W. Wanyonyi and O. Amuka (2016). Stem bark extracts of Erythrina excelsa (BAK) and their biological activities. Journal of Medicinal Plants Research Vol. 10(39), pp. 686-694, 17, DOI: 10.5897/JMPR2016.6070

  38.  F M. Mukora, HM Mbuvi, MM Nganga (2016). Remediation of water contaminated with Cr6+ and Cd2+ using aluminophosphates derived from ashes of tea leaves and pumpkins. Chemistry and Material Research 8 (7): 94

  39. Stephanie Oyola-Reynoso, Dickson Kihereko, Boyce Chang, James Mwangi, Julian Halberstma-Black, Jean-Francis Bloch, Martin Thuo, Margaret Nganga (2016). Substituting Plastic Casings with Perfluorosilane treated paper improves Biodegradability of Low-Cost Diagnostic Devices: Industrial Crops and products 94:294-298.

  40. Moses M Mbugua. Margaret M. Nganga and Harun M Mbuvi (2016). Removal of Lead ions and turbidity from waste water by adsorbent materials derived from Cactus leaves. Journal of Natural Sciences Research 6 (14): 63-72

  41. Benson M. Wachira, Paul Mireji, Sylvance Okoth, Margaret Nganga, Julius M William, Grace Murilla and Ahmed Hassanali (2016). Responses of Glossina morsitans morsitans tsetse flies to analogues of -octalactone and selected blends. Acta Tropica 160: 53-57.

  42. Nyamai DW, Muchugi A, Ng’ang’a M, Burugu MW (2015). Phytochemical Profile of Prunus Africana Stem Bark from Kenya. Journal of Pharmacognosy and Natural Products 1: 110. doi: 10.4172/jpnp.1000110.

  43. Nyamai DW, Ng’ang’a M. Burugu MW and Ramni Jamnadass (2015). Growth performance of domesticated Prunus africana population in Muguga, Kiambu County. Biochemistry & Physiology. 4:185. doi: 10.4172/2168- 9652.1000185

  44. Margaret Mwihaki Ng’ang’a, Hidayat Hussain, Sumesh Chhabra Caroline Langat-Thoruwa, Karsten Krohn, Javid Hussain, Ahmed-Al- Harrasi, Ivan Robert (2012). Eucleanal: A new naphthalene derivative from Euclea divinorum. Natural Products Communications 7 (2): 193-194:

  45. Margaret Mwihaki Ng’ang’a, Hidayat Hussain, Sumesh Chhabra Caroline Langat-Thoruwa, Karsten Krohn, Javid Hussain, Ahmed-Al- Harrasi, Ivan Robert (2012). Eucleanal A and B: Two new napthalene derivatives from Euclea divinorum. Chinese Chemical Letters 23: 576–578

  46. Margaret Mwihaki Ng’ang’a, Hidayat Hussain, Sumesh Chhabra Caroline Langat-Thoruwa, Beatrice Irungu, Ahmed Al-Harrasi Muhammed Riaz, Karsten Krohn (2012). Antiplasmodial activity of compounds from Drypetes gerrardi. Chemistry of Natural Compounds. 48: No. 2 (Russian Original No. 2 March –April 2012)

  47. Margaret Mwihaki Ng’ang’a, Hidayat Hussain, Sumesh Chhabra Caroline Langat-Thoruwa, Mohammed Riaz,Karsten Krohn, (2011). Drypetdimer A: A new flavones dimer from Drypetes gerrardi. Natural Products Communications 6: 1115-1116.

  48. Margaret Mwihaki Ng’ang’a, Hidayat Hussain, Sumesh Chhabra Caroline Langat-Thoruwa, Karsten Krohn (2009). Chemical constituents from the root bark of Ozoroa insignis. Biochemical Systematics and Ecology 37: 116-119

  49. Margaret Mwihaki Ng'ang'a, Sumesh Chhabra, Caroline Langat-Thoruwa, Hidayat Hussain Karsten Krohn (2008). Chemical constituents from the leaves of Drypetes gerrardii. Biochemical Systematics and Ecology 36: 320 – 322.

  50. Margaret Mwihaki Nganga (2008). Isolation and characterization of antimalarial compounds from selected medicinal plants used in Kenya. PhD thesis, Kenyatta University

  51. Wilson Njue, Margaret Mwihaki Njuguna, Richard Musau (1999). Determination of volatile impurities in alcoholic beverages using Gas-Liquid Chromatography. International Journal of Biochemistry. Physics 8: 44-47

  52. Wilson Njue., Margaret Mwihaki Njuguna, Richard Musau (1999). Determination of aflatoxins in alcoholic beverages and in their raw material. International Journal of Biochemistry. Physics 8: 44-47